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Data Sources: Centers for Medicare & Medicaid Services (CMS), Medicare Provider Utilization and Payment Data
Disclaimer: This site is an independent journalism project. Data analysis and editorial content are not affiliated with or endorsed by CMS or any government agency. All spending figures are based on publicly available Medicare payment records.
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ยฉ 2026 OpenMedicare. Independent data journalism. Built by TheDataProject.ai

Methodologyโ€ขDownload Data
  1. Home
  2. Providers
  3. Principle Labs Llc
๐Ÿ”ฌ
Organization

Principle Labs Llc

NPI: 1346648870
Bethlehem, PA
9 years of data
Clinical Laboratory
$26.6M
Total Payments
242
Beneficiaries
258.6K
Services
3.35x
Markup Ratio

Peer Comparison

96th
percentile in specialty
This provider$26.6M
Specialty median$1.9M

๐Ÿ“‹ Key Findings

1Billed $26.6M over 9 years
23.35x markup ratio (above median)
396th percentile in Clinical Laboratory by payments
4Payments surged 1531% in 2016
56 procedures with >3x markup
โœ“ No flags detected

๐Ÿ”Ž Data Analysis

This provider's $26.6M in total Medicare payments ranks in the 96th percentile of Clinical Laboratory providers nationally.

Medicare payments to this provider grew 36150% from 2015 to 2023.

AI-generated analysis based on Medicare payment data.

Annual Medicare Payments

Annual Services Provided

Avg Payment per Service

Markup Ratio Over Time

๐Ÿ“ˆ

Notable: Payments increased 1531% in 2016

Year-over-year payment surges can indicate changes in practice volume, new services, or billing pattern shifts.

Submitted Charges vs. Medicare Payments

Average per-service amounts submitted by the provider compared to what Medicare actually paid โ€” the gap represents the markup.

YearAvg SubmittedAvg PaidMarkup RatioGap per ServiceTotal PaymentsServicesBeneficiaries
2015$115.89$25.314.58x$90.58$12.5K4958
2016$1.6K$128.9812.36x$1.5K$204.3K1.6K6
2017$1.2K$117.0110.56x$1.1K$304.0K2.6K18
2018$981.03$93.0210.55x$888.01$998.7K10.7K38
2019$1.0K$134.637.48x$872.46$1.8M13.4K42
2020$737.68$249.232.96x$488.45$6.0M24.2K42
2021$718.87$265.432.71x$453.44$9.6M36.3K26
2022$104.21$48.512.15x$55.70$3.0M62.7K26
2023$80.85$42.611.90x$38.24$4.5M106.6K36

Top Procedures (20)

81408Molecular pathology procedure level 9
$5.6M
2.8K services$2.0K/svc1.50x markup
87798Detection test by nucleic acid for organism, amplified probe technique
$3.2M
92.6K services$34.47/svc1.69x markup
G0482Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/msโš  8.1x markup
$1.9M
9.9K services$195.91/svc8.14x markup
81411Test for detecting genes associated with heart disease, duplication/deletion analysis panel
$1.8M
1.3K services$1.3K/svc1.50x markup
81404Molecular pathology procedure level 5
$1.3M
4.8K services$274.16/svc1.50x markup
81407Molecular pathology procedure level 8
$1.3M
1.5K services$845.05/svc1.50x markup
G0483Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/msโš  12.5x markup
$1.1M
4.7K services$239.47/svc12.53x markup
80307Testing for presence of drug, by chemistry analyzersโš  7.8x markup
$1.1M
17.1K services$64.41/svc7.84x markup
G0481Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/msโš  7.6x markup
$1.0M
6.6K services$154.46/svc7.64x markup
81405Molecular pathology procedure level 6
$901.2K
3.0K services$300.91/svc1.50x markup
G0480Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/msโš  5.3x markup
$839.2K
7.5K services$112.64/svc5.27x markup
81406Molecular pathology procedure level 7
$837.2K
3.0K services$282.46/svc1.51x markup
81439Test for detecting genes associated with inherited disease of heart muscle
$780.8K
1.3K services$584.44/svc1.50x markup
87481Detection test for candida species (yeast), amplified probe technique
$705.0K
20.4K services$34.48/svc1.84x markup
U00042019-ncov coronavirus, sars-cov-2/2019-ncov (covid-19), any technique, multiple types or subtypes (includes all targets), non-cdc, making use of high throughput technologies as described by cms-2020-01-rโš  6.4x markup
$587.3K
7.2K services$82.06/svc6.42x markup
81161Gene analysis (dystrophin)
$371.3K
1.3K services$279.00/svc1.50x markup
81403Molecular pathology procedure level 4
$283.5K
1.5K services$184.94/svc1.51x markup
87653Detection test by nucleic acid for strep (streptococcus, group b), amplified probe technique
$241.0K
7.0K services$34.52/svc1.95x markup
87640Detection test by nucleic acid for staphylococcus aureus (bacteria), amplified probe technique
$238.8K
6.9K services$34.50/svc1.96x markup
81401Molecular pathology procedure level 2
$224.1K
1.6K services$136.65/svc1.53x markup
Show detailed table โ–พ
CodeDescriptionServicesPaymentsAvg/ServiceMarkup
81408Molecular pathology procedure level 92.8K$5.6M$2.0K1.50x
87798Detection test by nucleic acid for organism, amplified probe technique92.6K$3.2M$34.471.69x
G0482Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms9.9K$1.9M$195.918.14x
81411Test for detecting genes associated with heart disease, duplication/deletion analysis panel1.3K$1.8M$1.3K1.50x
81404Molecular pathology procedure level 54.8K$1.3M$274.161.50x
81407Molecular pathology procedure level 81.5K$1.3M$845.051.50x
G0483Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms4.7K$1.1M$239.4712.53x
80307Testing for presence of drug, by chemistry analyzers17.1K$1.1M$64.417.84x
G0481Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms6.6K$1.0M$154.467.64x
81405Molecular pathology procedure level 63.0K$901.2K$300.911.50x
G0480Drug test(s), definitive, utilizing (1) drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including, but not limited to gc/ms (any type, single or tandem) and lc/ms7.5K$839.2K$112.645.27x
81406Molecular pathology procedure level 73.0K$837.2K$282.461.51x
81439Test for detecting genes associated with inherited disease of heart muscle1.3K$780.8K$584.441.50x
87481Detection test for candida species (yeast), amplified probe technique20.4K$705.0K$34.481.84x
U00042019-ncov coronavirus, sars-cov-2/2019-ncov (covid-19), any technique, multiple types or subtypes (includes all targets), non-cdc, making use of high throughput technologies as described by cms-2020-01-r7.2K$587.3K$82.066.42x
81161Gene analysis (dystrophin)1.3K$371.3K$279.001.50x
81403Molecular pathology procedure level 41.5K$283.5K$184.941.51x
87653Detection test by nucleic acid for strep (streptococcus, group b), amplified probe technique7.0K$241.0K$34.521.95x
87640Detection test by nucleic acid for staphylococcus aureus (bacteria), amplified probe technique6.9K$238.8K$34.501.96x
81401Molecular pathology procedure level 21.6K$224.1K$136.651.53x

Markup Analysis

Charge-to-Payment Ratio

3.35x

This provider submits charges 3.35 times higher than what Medicare actually pays.

What This Means

A markup ratio of 3.35x means for every $100 Medicare pays, this provider initially charges $335. This is higher than the national average.

Location

Bethlehem, PA

Provider Verification

Always verify provider credentials and location before scheduling appointments. This data reflects Medicare payments and may not include all practice locations.

Similar Providers

Other Clinical Laboratory providers in PA for peer comparison.

Principle Labs Llc (you)
$26.6M
Quest Diagnostics Clinical Laboratories Inc
$340.6M
Quest Diagnostics Of Pennsylvania, Inc.โš ๏ธ
$130.4M
Health Network Laboratories, Llcโš ๏ธ
$125.3M
Sma Medical, Inc.
$100.9M
Interpace Diagnostics Corporation
$95.6M
Show detailed table โ–พ
ProviderLocationTotal PaymentsStatus
Quest Diagnostics Clinical Laboratories IncNorristown, PA$340.6Mโœ“ Clear
Quest Diagnostics Of Pennsylvania, Inc.Pittsburgh, PA$130.4Mโš ๏ธ Flagged
Health Network Laboratories, LlcAllentown, PA$125.3Mโš ๏ธ Flagged
Sma Medical, Inc.Feasterville, PA$100.9Mโœ“ Clear
Interpace Diagnostics CorporationPittsburgh, PA$95.6Mโœ“ Clear

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Data Sources

  • โ€ข Centers for Medicare & Medicaid Services (CMS)
  • โ€ข Medicare Provider Utilization and Payment Data (2014-2023)
  • โ€ข National Plan and Provider Enumeration System (NPPES)

Last Updated: February 2026 (data through 2023, the latest CMS release)

Note: All data is from publicly available Medicare records. OpenMedicare is an independent journalism project not affiliated with CMS.

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