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Data Sources: Centers for Medicare & Medicaid Services (CMS), Medicare Provider Utilization and Payment Data
Disclaimer: This site is an independent journalism project. Data analysis and editorial content are not affiliated with or endorsed by CMS or any government agency. All spending figures are based on publicly available Medicare payment records.
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Methodology•Download Data
  1. Home
  2. Providers
  3. Castle Biosciences, Inc
🔬
Organization

Castle Biosciences, Inc

NPI: 1770734253
Phoenix, AZ
10 years of data
Clinical Laboratory
$258.8M
Total Payments
27
Beneficiaries
41.5K
Services
1.31x
Markup Ratio

Peer Comparison

99th
percentile in specialty
This provider$258.8M
Specialty median$1.9M
Rank #40 of 232 in specialty

📋 Key Findings

1Billed $258.8M over 10 years
299th percentile in Clinical Laboratory by payments
3Payments surged 771% in 2018
44 procedures with >3x markup
✓ No flags detected

🔎 Data Analysis

This provider's $258.8M in total Medicare payments ranks in the 99th percentile of Clinical Laboratory providers nationally.

Medicare payments to this provider grew 15148% from 2014 to 2023.

65% of their billing comes from a single procedure code (81529 — Mrna gene analysis of 31 genes in skin melanoma tissue specimen).

AI-generated analysis based on Medicare payment data.

Annual Medicare Payments

Annual Services Provided

Avg Payment per Service

Markup Ratio Over Time

📈

Notable: Payments increased 771% in 2018

Year-over-year payment surges can indicate changes in practice volume, new services, or billing pattern shifts.

Submitted Charges vs. Medicare Payments

Average per-service amounts submitted by the provider compared to what Medicare actually paid — the gap represents the markup.

YearAvg SubmittedAvg PaidMarkup RatioGap per ServiceTotal PaymentsServicesBeneficiaries
2014$6.9K$2.0K3.42x$4.9K$465.1K2312
2015$8.0K$2.4K3.41x$5.7K$752.2K3201
2016$8.0K$4.0K2.00x$4.0K$1.3M3301
2017$8.2K$4.1K2.03x$4.2K$1.3M3282
2018$8.5K$4.1K2.10x$4.5K$11.6M2.9K1
2019$8.5K$5.6K1.52x$2.9K$28.6M5.1K2
2020$8.5K$6.9K1.22x$1.6K$35.0M5.0K2
2021$8.4K$7.0K1.19x$1.3K$48.0M6.8K3
2022$8.3K$6.9K1.21x$1.4K$60.7M8.8K4
2023$7.7K$6.1K1.26x$1.6K$70.9M11.6K9

Top Procedures (13)

81529Mrna gene analysis of 31 genes in skin melanoma tissue specimen
$167.4M
23.6K services$7.1K/svc1.20x markup
81599Multianalyte assay procedure with algorithmic analysis
$72.7M
12.4K services$5.9K/svc1.45x markup
81552Mrna gene expression analysis of 15 genes in eye melanoma o tissue or fine needle aspirate
$10.6M
1.5K services$6.9K/svc1.25x markup
84999Chemistry procedures
$3.5M
1.1K services$3.2K/svc2.48x markup
0090UMrna gene expression profiling of 23 genes in skin melanoma tissue sample
$2.0M
1.1K services$1.8K/svc2.36x markup
0081UOncology (uveal melanoma), mrna, gene-expression profiling by real-time rt-pcr of 15 genes (12 content and 3 housekeeping genes), utilizing fine needle aspirate or formalin-fixed paraffin-embedded tissue, algorithm reported as risk of metastasis
$1.6M
390 services$4.0K/svc2.13x markup
81418Genomic sequence analysis panel of at least 6 genes associated with drug metabolism⚠ 5.1x markup
$454.5K
493 services$921.85/svc5.10x markup
81479Molecular pathology procedure⚠ 3.1x markup
$236.7K
154 services$1.5K/svc3.06x markup
0411UPsyc genom alys pnl 15 gen⚠ 5.2x markup
$136.6K
152 services$898.74/svc5.23x markup
81226Gene analysis (cytochrome p450, family 2, subfamily d, polypeptide 6) common variants
$108.7K
246 services$441.89/svc1.93x markup
81225Gene analysis (cytochrome p450, family 2, subfamily c, polypeptide 19) common variants
$88.2K
309 services$285.53/svc1.90x markup
88381Preparation of specimen, manual⚠ 5.4x markup
$4.1K
34 services$120.74/svc5.38x markup
81227Gene analysis (cytochrome p450, family 2, subfamily c, polypeptide 9) common variants
$2.2K
13 services$171.31/svc2.99x markup
Show detailed table ▾
CodeDescriptionServicesPaymentsAvg/ServiceMarkup
81529Mrna gene analysis of 31 genes in skin melanoma tissue specimen23.6K$167.4M$7.1K1.20x
81599Multianalyte assay procedure with algorithmic analysis12.4K$72.7M$5.9K1.45x
81552Mrna gene expression analysis of 15 genes in eye melanoma o tissue or fine needle aspirate1.5K$10.6M$6.9K1.25x
84999Chemistry procedures1.1K$3.5M$3.2K2.48x
0090UMrna gene expression profiling of 23 genes in skin melanoma tissue sample1.1K$2.0M$1.8K2.36x
0081UOncology (uveal melanoma), mrna, gene-expression profiling by real-time rt-pcr of 15 genes (12 content and 3 housekeeping genes), utilizing fine needle aspirate or formalin-fixed paraffin-embedded tissue, algorithm reported as risk of metastasis390$1.6M$4.0K2.13x
81418Genomic sequence analysis panel of at least 6 genes associated with drug metabolism493$454.5K$921.855.10x
81479Molecular pathology procedure154$236.7K$1.5K3.06x
0411UPsyc genom alys pnl 15 gen152$136.6K$898.745.23x
81226Gene analysis (cytochrome p450, family 2, subfamily d, polypeptide 6) common variants246$108.7K$441.891.93x
81225Gene analysis (cytochrome p450, family 2, subfamily c, polypeptide 19) common variants309$88.2K$285.531.90x
88381Preparation of specimen, manual34$4.1K$120.745.38x
81227Gene analysis (cytochrome p450, family 2, subfamily c, polypeptide 9) common variants13$2.2K$171.312.99x

Markup Analysis

Charge-to-Payment Ratio

1.31x

This provider submits charges 1.31 times higher than what Medicare actually pays.

What This Means

A markup ratio of 1.31x means for every $100 Medicare pays, this provider initially charges $131. This is lower than the national average.

Location

Phoenix, AZ

Provider Verification

Always verify provider credentials and location before scheduling appointments. This data reflects Medicare payments and may not include all practice locations.

Similar Providers

Other Clinical Laboratory providers in AZ for peer comparison.

Castle Biosciences, Inc (you)
$258.8M
Sonora Quest Laboratories Llc⚠️
$565.3M
Laboratory Corporation Of America⚠️
$389.8M
Caris Mpi, Inc.⚠️
$382.6M
Genetic Technological Innovations, Llc⚠️
$93.5M
Show detailed table ▾
ProviderLocationTotal PaymentsStatus
Sonora Quest Laboratories LlcPhoenix, AZ$565.3M⚠️ Flagged
Laboratory Corporation Of AmericaPhoenix, AZ$389.8M⚠️ Flagged
Caris Mpi, Inc.Phoenix, AZ$382.6M⚠️ Flagged
Genetic Technological Innovations, LlcScottsdale, AZ$93.5M⚠️ Flagged

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Data Sources

  • • Centers for Medicare & Medicaid Services (CMS)
  • • Medicare Provider Utilization and Payment Data (2014-2023)
  • • National Plan and Provider Enumeration System (NPPES)

Last Updated: February 2026 (data through 2023, the latest CMS release)

Note: All data is from publicly available Medicare records. OpenMedicare is an independent journalism project not affiliated with CMS.

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