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Data Sources: Centers for Medicare & Medicaid Services (CMS), Medicare Provider Utilization and Payment Data
Disclaimer: This site is an independent journalism project. Data analysis and editorial content are not affiliated with or endorsed by CMS or any government agency. All spending figures are based on publicly available Medicare payment records.
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ยฉ 2026 OpenMedicare. Independent data journalism. Built by TheDataProject.ai

Methodologyโ€ขDownload Data
  1. Home
  2. Providers
  3. Ambry Genetics Corporation
๐Ÿ”ฌ
Organization

Ambry Genetics Corporation

NPI: 1861568784
Aliso Viejo, CA
10 years of data
Clinical Laboratory
$288.3M
Total Payments
125
Beneficiaries
293.0K
Services
2.53x
Markup Ratio

Peer Comparison

99th
percentile in specialty
This provider$288.3M
Specialty median$1.9M
Rank #35 of 232 in specialty

๐Ÿ“‹ Key Findings

1Billed $288.3M over 10 years
22.53x markup ratio (above median)
399th percentile in Clinical Laboratory by payments
4Payments surged 85% in 2015
511 procedures with >3x markup
โœ“ No flags detected

๐Ÿ”Ž Data Analysis

This provider's $288.3M in total Medicare payments ranks in the 99th percentile of Clinical Laboratory providers nationally.

Medicare payments to this provider grew 100% from 2014 to 2023.

61% of their billing comes from a single procedure code (81479 โ€” Molecular pathology procedure).

AI-generated analysis based on Medicare payment data.

Annual Medicare Payments

Annual Services Provided

Avg Payment per Service

Markup Ratio Over Time

๐Ÿ“ˆ

Notable: Payments increased 85% in 2015

Year-over-year payment surges can indicate changes in practice volume, new services, or billing pattern shifts.

Submitted Charges vs. Medicare Payments

Average per-service amounts submitted by the provider compared to what Medicare actually paid โ€” the gap represents the markup.

YearAvg SubmittedAvg PaidMarkup RatioGap per ServiceTotal PaymentsServicesBeneficiaries
2014$2.1K$770.232.73x$1.3K$20.4M26.5K15
2015$3.0K$853.173.49x$2.1K$37.8M44.3K18
2016$3.0K$742.994.04x$2.3K$39.1M52.6K19
2017$1.9K$717.302.67x$1.2K$30.6M42.6K17
2018$1.0K$608.011.71x$433.07$23.1M38.0K13
2019$2.0K$1.6K1.25x$407.17$19.4M12.0K13
2020$2.2K$1.4K1.57x$792.86$20.3M14.6K11
2021$2.0K$1.3K1.64x$795.91$23.6M18.8K9
2022$3.4K$1.6K2.06x$1.7K$33.3M20.4K7
2023$4.3K$1.8K2.46x$2.6K$40.8M23.2K3

Top Procedures (20)

81479Molecular pathology procedure
$176.0M
156.0K services$1.1K/svc2.66x markup
81162Gene analysis (breast cancer 1 and 2) of full sequence and analysis for duplication or deletion variants
$87.1M
41.7K services$2.1K/svc1.55x markup
81317Gene analysis (postmeiotic segregation increased 2 [S cerevisiae]) full sequence analysis
$7.9M
10.3K services$764.14/svc2.37x markup
81404Molecular pathology procedure level 5โš  4.5x markup
$5.2M
14.9K services$352.32/svc4.54x markup
81401Molecular pathology procedure level 2โš  7.8x markup
$2.2M
20.7K services$104.69/svc7.80x markup
81403Molecular pathology procedure level 4โš  14.1x markup
$2.0M
21.8K services$93.93/svc14.06x markup
81405Molecular pathology procedure level 6 genetic analysisโš  4.9x markup
$1.6M
4.0K services$388.93/svc4.87x markup
81406Molecular pathology procedure level 7โš  6.4x markup
$1.5M
4.2K services$359.81/svc6.38x markup
0129UGene analysis of genes associated with hereditary breast cancer and related disorders for gene sequence and duplication or deletion variantsโš  5.3x markup
$1.2M
946 services$1.3K/svc5.30x markup
81211Gene analysis (breast cancer 1 and 2) full sequence and common duplication or deletion variants
$778.4K
457 services$1.7K/svc2.18x markup
0101UGene sequence analysis panel of 15 genes associated with hereditary colon cancer and related disordersโš  4.0x markup
$649.9K
379 services$1.7K/svc3.97x markup
81300Gene analysis (mutS homolog 6 [E coli]) duplication or deletion variantsโš  6.4x markup
$467.2K
3.0K services$158.00/svc6.36x markup
U0003Infectious agent detection by nucleic acid (dna or rna); severe acute respiratory syndrome coronavirus 2 (sars-cov-2) (coronavirus disease [covid-19]), amplified probe technique, making use of high throughput technologies as described by cms-2020-01-r
$455.6K
5.5K services$82.91/svc1.39x markup
81323Gene analysis (phosphatase and tensin homolog), duplication or deletion variantโš  12.1x markup
$410.3K
4.8K services$85.80/svc12.14x markup
81213Gene analysis (breast cancer 1 and 2) uncommon duplication or deletion variants
$142.3K
263 services$540.94/svc2.27x markup
81321Gene analysis (phosphatase and tensin homolog), full sequence analysisโš  3.8x markup
$123.5K
209 services$590.88/svc3.77x markup
81292Gene analysis (mutL homolog 1, colon cancer, nonpolyposis type 2) full sequence analysis
$89.6K
142 services$631.23/svc2.87x markup
81212Gene analysis (breast cancer 1 and 2) for 185delag, 5385insc, 6174delt variants
$81.8K
253 services$323.29/svc2.62x markup
81295Gene analysis (muts homolog 2, colon cancer, nonpolyposis type 1) full sequence analysisโš  5.5x markup
$68.1K
291 services$233.93/svc5.53x markup
81201Gene analysis (adenomatous polyposis coli), full gene sequence
$63.5K
84 services$756.43/svc1.14x markup
Show detailed table โ–พ
CodeDescriptionServicesPaymentsAvg/ServiceMarkup
81479Molecular pathology procedure156.0K$176.0M$1.1K2.66x
81162Gene analysis (breast cancer 1 and 2) of full sequence and analysis for duplication or deletion variants41.7K$87.1M$2.1K1.55x
81317Gene analysis (postmeiotic segregation increased 2 [S cerevisiae]) full sequence analysis10.3K$7.9M$764.142.37x
81404Molecular pathology procedure level 514.9K$5.2M$352.324.54x
81401Molecular pathology procedure level 220.7K$2.2M$104.697.80x
81403Molecular pathology procedure level 421.8K$2.0M$93.9314.06x
81405Molecular pathology procedure level 6 genetic analysis4.0K$1.6M$388.934.87x
81406Molecular pathology procedure level 74.2K$1.5M$359.816.38x
0129UGene analysis of genes associated with hereditary breast cancer and related disorders for gene sequence and duplication or deletion variants946$1.2M$1.3K5.30x
81211Gene analysis (breast cancer 1 and 2) full sequence and common duplication or deletion variants457$778.4K$1.7K2.18x
0101UGene sequence analysis panel of 15 genes associated with hereditary colon cancer and related disorders379$649.9K$1.7K3.97x
81300Gene analysis (mutS homolog 6 [E coli]) duplication or deletion variants3.0K$467.2K$158.006.36x
U0003Infectious agent detection by nucleic acid (dna or rna); severe acute respiratory syndrome coronavirus 2 (sars-cov-2) (coronavirus disease [covid-19]), amplified probe technique, making use of high throughput technologies as described by cms-2020-01-r5.5K$455.6K$82.911.39x
81323Gene analysis (phosphatase and tensin homolog), duplication or deletion variant4.8K$410.3K$85.8012.14x
81213Gene analysis (breast cancer 1 and 2) uncommon duplication or deletion variants263$142.3K$540.942.27x
81321Gene analysis (phosphatase and tensin homolog), full sequence analysis209$123.5K$590.883.77x
81292Gene analysis (mutL homolog 1, colon cancer, nonpolyposis type 2) full sequence analysis142$89.6K$631.232.87x
81212Gene analysis (breast cancer 1 and 2) for 185delag, 5385insc, 6174delt variants253$81.8K$323.292.62x
81295Gene analysis (muts homolog 2, colon cancer, nonpolyposis type 1) full sequence analysis291$68.1K$233.935.53x
81201Gene analysis (adenomatous polyposis coli), full gene sequence84$63.5K$756.431.14x

Markup Analysis

Charge-to-Payment Ratio

2.53x

This provider submits charges 2.53 times higher than what Medicare actually pays.

What This Means

A markup ratio of 2.53x means for every $100 Medicare pays, this provider initially charges $253. This is higher than the national average.

Location

Aliso Viejo, CA

Provider Verification

Always verify provider credentials and location before scheduling appointments. This data reflects Medicare payments and may not include all practice locations.

Similar Providers

Other Clinical Laboratory providers in CA for peer comparison.

Ambry Genetics Corporation (you)
$288.3M
Genomic Health, Inc.
$887.6M
Unilab Corporationโš ๏ธ
$868.8M
Caredx Inc.
$751.0M
Laboratory Corporation Of Americaโš ๏ธ
$592.4M
Millennium Health, Llc
$587.9M
Show detailed table โ–พ
ProviderLocationTotal PaymentsStatus
Genomic Health, Inc.Redwood City, CA$887.6Mโœ“ Clear
Unilab CorporationWest Hills, CA$868.8Mโš ๏ธ Flagged
Caredx Inc.Brisbane, CA$751.0Mโœ“ Clear
Laboratory Corporation Of AmericaSan Diego, CA$592.4Mโš ๏ธ Flagged
Millennium Health, LlcSan Diego, CA$587.9Mโœ“ Clear

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Data Sources

  • โ€ข Centers for Medicare & Medicaid Services (CMS)
  • โ€ข Medicare Provider Utilization and Payment Data (2014-2023)
  • โ€ข National Plan and Provider Enumeration System (NPPES)

Last Updated: February 2026 (data through 2023, the latest CMS release)

Note: All data is from publicly available Medicare records. OpenMedicare is an independent journalism project not affiliated with CMS.

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